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Article

Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome.

Genes & development - 1 Jul 2008

Shen Haihong, Zheng Xuexiu, Shen Jingping, Zhang Lingdi, Zhao Rui, Green Michael R

Abstract excerpt

The essential splicing factor human UAP56 (hUAP56) is a DExD/H-box protein known to promote prespliceosome assembly. Here, using a series of hUAP56 mutants that are defective for ATP-binding, ATP hydrolysis, or dsRNA unwindase/helicase activity, we assess the relative contributions of these biochemical functions to pre-mRNA splicing. We show that prespliceosome assembly requires hUAP56's ATP-binding and ATPase...

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Share to DEAD-box RNA Helicases
Share to Ribonucleoprotein, U4-U6 Small Nuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to RNA, Double-Stranded

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Share to RNA, Small Nuclear

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Source

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Identifiers

PMID: 18593880
DOI: 10.1101/gad.1657308
PMCID: PMC2492666

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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