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Article

The network of protein–protein interactions within the human U4/U6.U5 tri-snRNP

24 May 2006

Abstract excerpt

The human 25S U4/U6.U5 tri-snRNP is a major building block of the U2-type spliceosome and contains, in addition to the U4, U6, and U5 snRNAs, at least 30 distinct proteins. To learn more about the molecular architecture of the tri-snRNP, we have investigated interactions between tri-snRNP proteins using the yeast two-hybrid assay and in vitro binding assays, and, in addition, have identified distinct protein...

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Identifiers

PMID: 16723661
DOI: 10.1261/rna.55406

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