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Article

A role for ubiquitin in the spliceosome assembly pathway.

Nature structural & molecular biology - 1 May 2008

Bellare Priya, Small Eliza C, Huang Xinhua, Wohlschlegel James A, Staley Jonathan P, Sontheimer Erik J

Abstract excerpt

The spliceosome uses numerous strategies to regulate its function in mRNA maturation. Ubiquitin regulates many cellular processes, but its potential roles during splicing are unknown. We have developed a new strategy that reveals a direct role for ubiquitin in the dynamics of splicing complexes. A ubiquitin mutant (I44A) that can enter the conjugation pathway but is compromised in downstream functions diminishes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18425143
DOI: 10.1038/nsmb.1401
PMCID: PMC2737727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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