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Article

The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Feb 2013

Dougherty Joseph D, Maloney Susan E, Wozniak David F, Rieger Michael A, Sonnenblick Lisa, Coppola Giovanni, Mahieu Nathaniel G, Zhang Juliet, Cai Jinlu, Patti Gary J, Abrahams Brett S, Geschwind Daniel H, Heintz Nathaniel

Abstract excerpt

The immense molecular diversity of neurons challenges our ability to understand the genetic and cellular etiology of neuropsychiatric disorders. Leveraging knowledge from neurobiology may help parse the genetic complexity: identifying genes important for a circuit that mediates a particular symptom of a disease may help identify polymorphisms that contribute to risk for the disease as a whole. The serotonergic...

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Identifiers

PMID: 23407934
DOI: 10.1523/JNEUROSCI.4762-12.2013
PMCID: PMC3711589

Genes

CELF6

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