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Article

Protocadherin α (PCDHA) as a novel susceptibility gene for autism.

Journal of psychiatry & neuroscience : JPN - 1 May 2013

Anitha Ayyappan, Thanseem Ismail, Nakamura Kazuhiko, Yamada Kazuo, Iwayama Yoshimi, Toyota Tomoko, Iwata Yasuhide, Suzuki Katsuaki, Sugiyama Toshiro, Tsujii Masatsugu, Yoshikawa Takeo, Mori Norio

Abstract excerpt

BACKGROUND: Synaptic dysfunction has been shown to be involved in the pathogenesis of autism. We hypothesized that the protocadherin α gene cluster (PCDHA), which is involved in synaptic specificity and in serotonergic innervation of the brain, could be a suitable candidate gene for autism. METHODS: We examined 14 PCDHA single nucleotide polymorphisms (SNPs) for genetic association with autism in DNA samples of...

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Identifiers

PMID: 23031252
DOI: 10.1503/jpn.120058
PMCID: PMC3633712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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