Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis.

doi:10.1128/JCM.43.1.406-413.2005

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Article

Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysis.

Journal of clinical microbiology - 1 Jan 2005

Palmer Sarah, Kearney Mary, Maldarelli Frank, Halvas Elias K, Bixby Christian J, Bazmi Holly, Rock Diane, Falloon Judith, Davey Richard T, Dewar Robin L, Metcalf Julia A, Hammer Scott, Mellors John W, Coffin John M

Abstract excerpt

To investigate the extent to which drug resistance mutations are missed by standard genotyping methods, we analyzed the same plasma samples from 26 patients with suspected multidrug-resistant human immunodeficiency virus type 1 by using a newly developed single-genome sequencing technique and compared it to standard genotype analysis. Plasma samples were obtained from patients with prior exposure to at least two...

Topics

Anti-HIV Agents
Drug Resistance, Multiple, Viral
Genome, Viral
Genotype
HIV Infections
HIV Protease
HIV Reverse Transcriptase
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microbial Sensitivity Tests

Mutation

RNA, Viral

Reverse Transcriptase Inhibitors

Sensitivity and Specificity

Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 15635002
DOI: 10.1128/JCM.43.1.406-413.2005
PMCID: PMC540111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15635002-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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