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Article

A mutational shift from domain III to II in the internal ribosome entry site of hepatitis C virus after interferon-ribavirin therapy.

Archives of virology - 1 Jan 2008

Ogata Kei, Kashiwagi Takahito, Iwahashi Jun, Hara Koyu, Honda Haruhito, Ide Tatsuya, Kumashiro Ryukichi, Kohara Michinori, Sata Michio, Watanabe Hiroshi, Hamada Nobuyuki

Abstract excerpt

We focused on the relationship between variation in the IRES of hepatitis C virus (HCV) genotype 1b and clinical outcome, since the internal ribosome entry site (IRES) has a comparatively low heterogeneity and it might be easy to find unique substitutions. Patients infected with HCV were selected using strict criteria, and unique mutations in the IRES were extracted by the subtraction of common mutations. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18592133
DOI: 10.1007/s00705-008-0143-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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