Analysis of genotype 1b hepatitis C virus IRES in serum and peripheral blood mononuclear cells in patients treated with interferon and ribavirin.

doi:10.1155/2014/175405

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Article

Analysis of genotype 1b hepatitis C virus IRES in serum and peripheral blood mononuclear cells in patients treated with interferon and ribavirin.

BioMed research international - 1 Jan 2014

Bukowska-Ośko Iwona, Caraballo Cortés Kamila, Pawełczyk Agnieszka, Płoski Rafał, Fic Maria, Perlejewski Karol, Demkow Urszula, Berak Hanna, Horban Andrzej, Laskus Tomasz, Radkowski Marek

Abstract excerpt

Hepatitis C virus (HCV) highly conserved IRES (internal ribosome entry site) sequence, localized within the 5(')-untranslated region (5(')UTR), may determine viral properties like replication efficiency and cell tropism. The aim of the present study was to characterize newly emerging 5(')UTR variants in serum and peripheral blood mononuclear cells (PBMC) in chronic hepatitis C patients treated with interferon...

Topics

5' Untranslated Regions
Adult
Aged
Antiviral Agents
Female
Genotype
Hepacivirus
Hepatitis C
Humans
Interferon-alpha
Leukocytes, Mononuclear
Male
Middle Aged

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Point Mutation

RNA, Viral

Regulatory Sequences, Ribonucleic Acid

Ribavirin

Viral Tropism

Source

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Identifiers

PMID: 25136559
DOI: 10.1155/2014/175405
PMCID: PMC4106116

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