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Article

Mutational analysis of the apical region of domain II of the HCV IRES.

FEBS letters - 30 Jan 2002

Kalliampakou Katerina I, Psaridi-Linardaki Loukia, Mavromara Penelope

Abstract excerpt

The hepatitis C virus internal ribosome entry site (IRES) binds directly to the 40S ribosomal subunit via domains III/IV while domain II induces conformational changes on the ribosome which have been implicated in the decoding process. Here, we performed an extensive mutational study within the apical portion of domain II in order to address the functional role of this region on translation. Our results showed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11821053
DOI: 10.1016/s0014-5793(01)03300-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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