Article
Phenotypic and functional analysis of dendritic cells and clinical outcome in patients with high-risk melanoma treated with adjuvant granulocyte macrophage colony-stimulating factor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jul 2008
Daud Adil I, Mirza Noweeda, Lenox Brianna, Andrews Stephanie, Urbas Patricia, Gao Gui X, Lee Ji-Hyun, Sondak Vernon K, Riker Adam I, Deconti Ronald C, Gabrilovich Dmitry
Abstract excerpt
PURPOSE: Granulocyte macrophage colony-stimulating factor (GM-CSF) can induce differentiation of dendritic cells (DCs) in preclinical models. We hypothesized that GM-CSF-stimulated DC differentiation may result in clinical benefit in patients with high-risk melanoma. PATIENTS AND METHODS: We conducted a prospective trial in patients with high-risk (stage III B/C, IV), resected melanoma, with GM-CSF 125...
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