Article
Comparative genomic profiling of Dutch clinical Bordetella pertussis isolates using DNA microarrays: identification of genes absent from epidemic strains.
BMC genomics - 30 Jun 2008
King Audrey J, van Gorkom Tamara, Pennings Jeroen L A, van der Heide Han G J, He Qiushui, Diavatopoulos Dimitri, Heuvelman Kees, van Gent Marjolein, van Leeuwen Karin, Mooi Frits R
Abstract excerpt
BACKGROUND: Whooping cough caused by Bordetella pertussis in humans, is re-emerging in many countries despite vaccination. Several studies have shown that significant shifts have occurred in the B. pertussis population resulting in antigenic divergence between vaccine strains and circulating strains and suggesting pathogen adaptation. In the Netherlands, the resurgence of pertussis is associated with the rise of...
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