Article
Differentially expressed genes in Bordetella pertussis strains belonging to a lineage which recently spread globally.
PloS one - 1 Jan 2014
de Gouw Daan, Hermans Peter W M, Bootsma Hester J, Zomer Aldert, Heuvelman Kees, Diavatopoulos Dimitri A, Mooi Frits R
Abstract excerpt
Pertussis is a highly contagious, acute respiratory disease in humans caused by the Gram-negative pathogen Bordetella pertussis. Pertussis has resurged in the face of intensive vaccination and this has coincided with the emergence of strains carrying a particular allele for the pertussis toxin promoter, ptxP3, which is associated with higher levels of pertussis toxin (Ptx) production. Within 10 to 20 years, ptxP3...
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