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Article

Contribution of amino acid region 334-335 from factor Va heavy chain to the catalytic efficiency of prothrombinase.

Biochemistry - 1 Jul 2008

Barhoover Melissa A, Orban Tivadar, Beck Daniel O, Bukys Michael A, Kalafatis Michael

Abstract excerpt

We have demonstrated that amino acids E (323), Y (324), E (330), and V (331) from the factor Va heavy chain are required for the interaction of the cofactor with factor Xa and optimum rates of prothrombin cleavage. We have also shown that amino acid region 332-336 contains residues that are important for cofactor function. Using overlapping peptides, we identified amino acids D (334) and Y (335) as contributors...

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Identifiers

PMID: 18537263
DOI: 10.1021/bi800057r
PMCID: PMC2652359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Contribution of amino acid region 334-335 from factor Va heavy chain to the catalytic efficiency of prothrombinase.PMID 18537263Read ↗

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