Article
The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis.
Thrombosis and haemostasis - 1 Jan 2004
Saleh Mahasen, Peng Weimin, Quinn-Allen Mary Ann, Macedo-Ribeiro Sandra, Fuentes-Prior Pablo, Bode Wolfram, Kane William H
Abstract excerpt
The contribution of the factor Va C1 domain (fVa-C1) to assembly of the prothrombinase complex has not been previously investigated. The homologous fVa-C2 domain contains a binding site for phosphatidylserine (PS) that includes the indole moieties of Trp(2063)/Trp(2064) at the apex of spike-1. In order to investigate the structure and function of fVa-C1 a molecular model was constructed based on the structure of...
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