Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

17 Apr 2018

Abstract excerpt

Reduced choroidal blood flow and tissue changes in the ageing human eye impair oxygen delivery to photoreceptors and the retinal pigment epithelium. As a consequence, mild but chronic hypoxia may develop and disturb cell metabolism, function and ultimately survival, potentially contributing to retinal pathologies such as age-related macular degeneration (AMD). Here, we show that several hypoxia-inducible genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Mitochondrial Function and Pathology
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29666476
DOI: 10.1038/s41418-018-0094-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stressPMID 29666476Read ↗

Hypoxia-Inducible Factor-1 (HIF-1): A Potential Target for Intervention in Ocular Neovascular DiseasesSemantic proximity Read ↗

Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration.Semantic proximity Read ↗

A novel multiplex RNAi therapy simultaneously targets <i>Hif1a</i> and <i>Hif2a</i> to defy retinal degeneration in two models of AMDSemantic proximity Read ↗

Hypoxia and aging: molecular mechanisms, diseases, and therapeutic targetsSemantic proximity Read ↗

Distinct Signature of Altered Homeostasis in Aging Rod Photoreceptors: Implications for Retinal DiseasesSemantic proximity Read ↗

Roles of Hypoxia Response in Retinal Development and PathophysiologySemantic proximity Read ↗

Hypoxia in the Eye: A Two-Sided CoinSemantic proximity Read ↗

Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activationSemantic proximity Read ↗

High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3Semantic proximity Read ↗

PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD PathogenesisSemantic proximity Read ↗

Intermittent hypoxia promotes functional neuroprotection from retinal ischemia in untreated first-generation offspringSemantic proximity Read ↗

Regulatory role of HIF-1α in the pathogenesis of age-related macular degeneration (AMD)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.