Article
Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Nov 1996
Oster-Granite M L, McPhie D L, Greenan J, Neve R L
Abstract excerpt
The molecular basis for the degeneration of neurons and the deposition of amyloid in plaques and in the cerebrovasculature in Alzheimer's disease (AD) is incompletely understood. We have proposed that one molecule common to these abnormal processes is a fragment of the Alzheimer amyloid precursor...
Topics
- Age Factors
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Axons
- Cytoskeleton
- Dendrites
- Disease Models, Animal
- Dystrophin
- Female
- Gene Expression
- Hippocampus
- Lysosomes
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Microscopy, Electron
- Mutation