Article
Selective vulnerability of dentate granule cells prior to amyloid deposition in PDAPP mice: digital morphometric analyses.
Proceedings of the National Academy of Sciences of the United States of America - 4 May 2004
Wu Chi-Cheng, Chawla Faisal, Games Dora, Rydel Russell E, Freedman Stephen, Schenk Dale, Young Warren G, Morrison John H, Bloom Floyd E
Abstract excerpt
Increasing evidence from mouse models of Alzheimer's disease shows that overexpression of a mutant form of the amyloid precursor protein (APP) and its product, beta-amyloid peptide, initiate pathological changes before amyloid deposition. To evaluate the cytological basis for one of these early changes, namely reduced volume of the dentate gyrus (DG), we have used high-throughput diOlistic cell loading and 3D...
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