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Article

BMP4 and Wnt signaling interact to promote mouse tracheal mesenchyme morphogenesis.

American journal of physiology. Lung cellular and molecular physiology - 1 Feb 2022

Bottasso-Arias Natalia, Leesman Lauren, Burra Kaulini, Snowball John, Shah Ronak, Mohanakrishnan Megha, Xu Yan, Sinner Debora

Abstract excerpt

Tracheobronchomalacia and complete tracheal rings are congenital malformations of the trachea associated with morbidity and mortality for which the etiology remains poorly understood. Epithelial expression of Wls (a cargo receptor mediating Wnt ligand secretion) by tracheal cells is essential for patterning the embryonic mouse trachea's cartilage and muscle. RNA sequencing indicated that Wls differentially...

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Identifiers

PMID: 34851738
DOI: 10.1152/ajplung.00255.2021
PMCID: PMC8794023

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