Article

Loss of PRDM16 Drives Nasal Septal Deviation through Dysregulated TGFβ2 Signaling

2026-07-29

Abstract excerpt

Nasal septal deviation affects approximiately 20% of newborns globally and 80% individuals in the United States. GWAS have linked PRDM16, a histone methyltransferase, to craniofacial abnormalities, yet its role in nasal septum development remains poorly understood. Global Prdm16 knockout mice ( Prdm16 -/- ) exhibit severe craniofacial defects resembling Pierre Robin Syndrome but are neonatally lethal, precluding...

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Literature Corpus work: 390404fa-6604-5ebb-b3fd-16ce10e489cc
DOI: 10.64898/2026.07.28.741259

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