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Article

Two-stage designs to identify the effects of SNP combinations on complex diseases.

Journal of human genetics - 1 Jan 2008

Kang Guolian, Yue Weihua, Zhang Jifeng, Huebner Marianne, Zhang Handi, Ruan Yan, Lu Tianlan, Ling Yansu, Zuo Yijun, Zhang Dai

Abstract excerpt

The genetic basis of complex diseases is expected to be highly heterogeneous, with many disease genes, where each gene by itself has only a small effect. Based on the nonlinear contributions of disease genes across the genome to complex diseases, we introduce the concept of single nucleotide polymorphism (SNP) synergistic blocks. A two-stage approach is applied to detect the genetic association of synergistic...

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PMID: 18584117
DOI: 10.1007/s10038-008-0307-x

Genes

FZD3
NRG1
RGS4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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