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Article

Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization.

The Journal of clinical endocrinology and metabolism - 1 Sept 2008

Vettor Roberto, Granzotto Marnie, De Stefani Diego, Trevellin Elisabetta, Rossato Marco, Farina Maria Grazia, Milan Gabriella, Pilon Catia, Nigro Angela, Federspil Giovanni, Vigneri Riccardo, Vitiello Libero, Rizzuto Rosario, Baratta Roberto, Frittitta Lucia

Abstract excerpt

BACKGROUND: Free fatty acids (FFAs) acutely stimulate but chronically impair glucose-stimulated insulin secretion from beta-cells. The G protein-coupled transmembrane receptor 40 (GPR40) mediates both acute and chronic effects of FFAs on insulin secretion and plays a role in glucose homeostasis. Limited information is available on the effect of GPR40 genetic abnormalities on insulin secretion and metabolic...

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Identifiers

PMID: 18583466
DOI: 10.1210/jc.2007-2680

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization.PMID 18583466Read ↗

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