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Article

Low mannose-binding lectin function is associated with sepsis in adult patients.

FEMS immunology and medical microbiology - 1 Nov 2006

Eisen Damon P, Dean Melinda M, Thomas Peter, Marshall Penny, Gerns Natalie, Heatley Sue, Quinn Josephine, Minchinton Robyn M, Lipman Jeff

Abstract excerpt

Mannose-binding lectin (MBL) is an innate immune system pattern recognition molecule that kills a wide range of pathogens via the lectin complement pathway. MBL deficiency is associated with severe infection but the best measure of this deficiency is undecided. We investigated the influence of MBL functional deficiency on the development of sepsis in 195 adult patients, 166 of whom had bloodstream infection and...

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Identifiers

PMID: 17064281
DOI: 10.1111/j.1574-695X.2006.00144.x

Genes

MBL2

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