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Article

RecQ and RecG helicases have distinct roles in maintaining the stability of polypurine.polypyrimidine sequences.

Mutation research - 25 Aug 2008

Dixon Bradley P, Lu Lu, Chu Albert, Bissler John J

Abstract excerpt

DNA triplex structures can block the replication fork and result in double-stranded DNA breaks (DSBs). RecQ and RecG helicases may be important for replication of such sequences as RecQ resolves synthetic triplex DNA structures and RecG mediates replication restart by fork regression. Primer extension on an 88 bp triplex-forming polypurine.polypyrimidine (Pu.Py) tract from the PKD1 gene demonstrated that RecQ,...

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Share to DNA Replication
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18582477
DOI: 10.1016/j.mrfmmm.2008.05.005
PMCID: PMC2667899

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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