Article

Developmental and transcriptional programs that define the initiation of the forelimb

2025-11-25

Abstract excerpt

<h4>ABSTRACT</h4> The vertebrate forelimb initiates as a localized swelling in the somatic lateral plate mesoderm (somatic LPM) in response to TBX5-dependent transcription. The molecular pathways driving limb morphogenesis have been extensively studied but the steps directly preceding limb bud formation remain poorly characterized. To address this, we defined the temporal onset of forelimb initiation in mouse emb...

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Literature Corpus work: 633e1340-baee-5fc9-bcd8-4030491361c5
DOI: 10.1101/2025.11.23.689776

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