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Article

Shh signaling influences the phenotype of Pitx1-/- hindlimbs.

Developmental biology - 15 Jul 2018

Nemec Stephen, Sung Aurélie Huang, Drouin Jacques

Abstract excerpt

Forelimbs (FLs) and hindlimbs (HLs) develop under the instructive and integrated guidance of signaling centers and transcription factor (TF) action. The development of structures specific to each limb type depends on the limb-specific modulation of these integrated components. Pitx1 is a transcription factor gene expressed in HL, absent in FL, and required for HL-specific patterning and development, in particular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29705333
DOI: 10.1016/j.ydbio.2018.04.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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