Article
Genetic heterogeneity of susceptibility gene in different ethnic populations: refining association study of PTPN22 for Graves' disease in a Chinese Han population.
PloS one - 1 Jan 2013
Xue Liqiong, Pan Chunming, Gu Zhaohui, Zhao Shuangxia, Han Bing, Liu Wei, Yang Shaoying, Yu Shasha, Sun Yixuan, Liang Jun, Gao Guanqi, Zhang Xiaomei, Yuan Guoyue, Li Changgui, Du Wenhua, Chen Gang, Chen Jialun, Song Huaidong
Abstract excerpt
In our previous studies, we presumed subtypes of Graves' disease (GD) may be caused by different major susceptibility genes or different variants of a single susceptibility gene. However, more evidence is needed to support this hypothesis. Single-nucleotide polymorphism (SNP) rs2476601 in PTPN22 is the susceptibility loci of GD in the European population. However, this polymorphism has not been found in Asian...
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