Article
CHD5 , a Tumor Suppressor Gene Deleted From 1p36.31 in Neuroblastomas
24 Jun 2008
Abstract excerpt
BACKGROUND: Neuroblastomas are characterized by hemizygous 1p deletions, suggesting that a tumor suppressor gene resides in this region. We previously mapped the smallest region of consistent deletion to a 2-Mb region of 1p36.31 that encodes 23 genes. Based on mutation analysis, expression pattern, and putative function, we identified CHD5 as the best tumor suppressor gene candidate. METHODS: We determined the...