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Article

Mechanisms of CHD5 Inactivation in Neuroblastomas

1 Feb 2012

Abstract excerpt

PURPOSE: Neuroblastomas (NBs) have genomic, biological, and clinical heterogeneity. High-risk NBs are characterized by several genomic changes, including MYCN amplification and 1p36 deletion. We identified the chromatin-remodeling gene CHD5 as a tumor suppressor gene that maps to 1p36.31. Low or absent CHD5 expression is associated with a 1p36 deletion and an unfavorable outcome, but the mechanisms of CHD5...

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PMID: 22294723
DOI: 10.1158/1078-0432.ccr-11-2644

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