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Article

CHD5 inhibits metastasis of neuroblastoma

17 Nov 2021

Abstract excerpt

CHD5, a tumor suppressor at 1p36, is frequently lost or silenced in poor prognosis neuroblastoma (NB) and many adult cancers. The role of CHD5 in metastasis is unknown. We confirm that low expression of CHD5 is associated with stage 4 NB. Forced expression of CHD5 in NB cell lines with 1p loss inhibited key aspects of the metastatic cascade in vitro: anchorage-independent growth, migration, and invasion. In vivo,...

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Identifiers

PMID: 34789839
DOI: 10.1038/s41388-021-02081-0

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