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Article

Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia.

Blood - 1 Sept 2008

Rassenti Laura Z, Jain Sonia, Keating Michael J, Wierda William G, Grever Michael R, Byrd John C, Kay Neil E, Brown Jennifer R, Gribben John G, Neuberg Donna S, He Feng, Greaves Andrew W, Rai Kanti R, Kipps Thomas J

Abstract excerpt

Leukemia-cell expression of ZAP-70, CD38, or unmutated immunoglobulin heavy chain variable region genes (U-IGHV) each is associated with aggressive disease in patients with chronic lymphocytic leukemia (CLL). To assess the relative strength of each marker, we defined thresholds for designating a case as positive for CD38 or ZAP-70 in a test cohort of 307 patients and used these data-defined criteria to stratify...

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Identifiers

PMID: 18577710
DOI: 10.1182/blood-2007-05-092882
PMCID: PMC2518894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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