Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zap-70 and CD38 as predictors of IgVH mutation in CLL.

Experimental and molecular pathology - 1 Dec 2007

Cruse Julius M, Lewis Robert E, Webb Rachel N, Sanders Catherine M, Suggs Jeanann L

Abstract excerpt

Zeta-chain (TCR)-associated protein kinase 70 kDa (Zap-70) and CD38 expression may be of prognostic significance in chronic lymphocytic leukemia (CLL). Previous studies indicate that Zap-70 and CD38 are usually positive in cases of CLL with unmutated immunoglobulin variable region genes (IgVH) and may be used to predict IgVH mutation status and prognosis. Usually cases of CLL positive for Zap-70 or CD38 indicate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADP-ribosyl Cyclase 1
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Membrane Glycoproteins

Share to Mutation

Share to Prognosis

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 17931624
DOI: 10.1016/j.yexmp.2007.08.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zap-70 and CD38 as predictors of IgVH mutation in CLL.PMID 17931624Read ↗

Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia.Semantic proximity Read ↗

Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

ZAP-70 and CD38 expression are independent prognostic factors in patients with B-cell chronic lymphocytic leukaemia and combined analysis improves their predictive value.Semantic proximity Read ↗

Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia.Semantic proximity Read ↗

Significance of VH genes mutation status for prognosis of CLL patients.Semantic proximity Read ↗

Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia.Semantic proximity Read ↗

Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia.Semantic proximity Read ↗

Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.Semantic proximity Read ↗

Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

ZAP-70 expression and prognosis in chronic lymphocytic leukaemia.Semantic proximity Read ↗

ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.Semantic proximity Read ↗

ZAP70 in B-CLL cells related to the expression in NK cells is a surrogate marker for mutational status.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.