Article
CD38 expression level and pattern of expression remains a reliable and robust marker of progressive disease in chronic lymphocytic leukemia.
Leukemia & lymphoma - 1 Nov 2006
Hayat Amjad, O'Brien David, O'Rourke Paul, McGuckin Siobhan, Fitzgerald Tony, Conneally Eibhlin, Browne Paul V, McCann Shaun R, Lawler Mark P, Vandenberghe Elisabeth
Abstract excerpt
Chronic lymphocytic leukemia (CLL) follows a variable clinical course which is difficult to predict at diagnosis. We assessed somatic mutation (SHM) status, CD38 and ZAP-70 expression in 87 patients (49 male, 38 female) with stage A CLL and known cytogenetic profile to compare their role in predicting disease progression, which was assessed by the treatment free interval (TFI) from diagnosis. Sixty (69%) patients...
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