Article
Labeling of human clots in vitro with an active-site mutant of t-PA.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Feb 1990
Fry E T, Mack D L, Monge J C, Billadello J J, Sobel B E
Abstract excerpt
Prompt detection of acute thrombosis and its response to treatment with thrombolytic agents generally require angiography. Scintigraphic approaches with labeled antibodies to or components of the coagulation and fibrinolytic systems have been disappointing because of prolonged circulating half-lives of tracers and relatively slow or limited binding to thrombi. Accordingly, we developed and characterized a...
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