Article
No evidence for genetic association of interferon regulatory factor 1 in juvenile idiopathic arthritis.
Arthritis and rheumatism - 1 Mar 2007
Fife Mark S, Gathercole Laura, Ogilvie Emma M, Stock Carmel J W, Mack Lisa F, Donn Rachelle P, Thomson Wendy, Woo Patricia
Abstract excerpt
OBJECTIVE: Juvenile idiopathic arthritis (JIA) comprises several clinically distinct subgroups and is the most widespread cause of chronic childhood disability. A significant association between JIA and a polymorphism in the interferon regulatory factor 1 (IRF-1) gene has previously been reported, implicating IRF1 in disease susceptibility. The aim of this study was to replicate the IRF1 association in JIA using...
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