Article
Evolutionary-based grouping of haplotypes in association analysis.
Genetic epidemiology - 1 Apr 2005
Tzeng Jung-Ying
Abstract excerpt
Haplotypes incorporate more information about the underlying polymorphisms than do genotypes for individual SNPs, and are considered as a more informative format of data in association analysis. To model haplotypes requires high degrees of freedom, which could decrease power and limit a model's capacity to incorporate other complex effects, such as gene-gene interactions. Even within haplotype blocks, high...
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