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PDCL2 is essential for spermiogenesis and male fertility in mice

17 Oct 2022

Abstract excerpt

Abstract Patients with teratozoospermia exhibit low phosducin-like protein (Pdcl2) expression. As a member of the phosducin family, chaperonin-related Pdcl2, a germline-specific gene, may be involved in germ cell protein folding. Given that PDCL2 is highly conserved in evolution, it may be indispensable for mammalian spermiogenesis; however, the function of PDCL2 in higher mammalian species remains unknown. To...

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PMID: 36253364
DOI: 10.1038/s41420-022-01210-2

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