Opposite Effects of Interleukin-1α and Transforming Growth Factor-β2 Induce Stage-Specific Regulation of Junctional Adhesion Molecule-B Gene in Sertoli Cells

Abstract excerpt

In the mammalian testis, junctional adhesion molecule-B (JAM-B) is found at the blood-testis barrier between Sertoli cells and the apical ectoplasmic specializations between Sertoli and germ cells. The expression of JAM-B is tightly regulated to allow the transit of developing germ cells across the blood-testis barrier and the timely release of mature spermatids at stage VIII. In this study, the basal...

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