Article
The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation.
Molecular and cellular biology - 1 Jul 2004
Van Eynde Aleyde, Nuytten Mieke, Dewerchin Mieke, Schoonjans Luc, Keppens Stefaan, Beullens Monique, Moons Lieve, Carmeliet Peter, Stalmans Willy, Bollen Mathieu
Abstract excerpt
NIPP1 (nuclear inhibitor of protein phosphatase 1) is a ubiquitously expressed nuclear scaffold protein that has been implicated in both transcription and RNA processing. Among its protein ligands are a protein kinase, a protein phosphatase, two splicing factors, and a transcriptional regulator, and the binding of these proteins to NIPP1 is tightly regulated by phosphorylation. To study the function of NIPP1 in...
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