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Article

ERK5 promotes Src-induced podosome formation by limiting Rho activation.

The Journal of cell biology - 30 Jun 2008

Schramp Mark, Ying Olivia, Kim Tai Young, Martin G Steven

Abstract excerpt

Increased Src activity, often associated with tumorigenesis, leads to the formation of invasive adhesions termed podosomes. Podosome formation requires the function of Rho family guanosine triphosphatases and reorganization of the actin cytoskeleton. In addition, Src induces changes in gene expression required for transformation, in part by activating mitogen-activated protein kinase (MAPK) signaling pathways. We...

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Identifiers

PMID: 18573916
DOI: 10.1083/jcb.200801078
PMCID: PMC2442207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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