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Article

Doubles game: Src-Stat3 versus p53-PTEN in cellular migration and invasion.

Molecular and cellular biology - 1 Nov 2010

Mukhopadhyay Utpal K, Mooney Patrick, Jia Lilly, Eves Robert, Raptis Leda, Mak Alan S

Abstract excerpt

We have recently shown that Src induces the formation of podosomes and cell invasion by suppressing endogenous p53, while enhanced p53 strongly represses the Src-induced invasive phenotype. However, the mechanism by which Src and p53 play antagonistic roles in cell invasion is unknown. Here we show that the Stat3 oncogene is a required downstream effector of Src in inducing podosome structures and related...

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Source

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Identifiers

PMID: 20733006
DOI: 10.1128/MCB.00004-10
PMCID: PMC2953057

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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