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Abl-mediated PI3K activation regulates macrophage podosome formation

11 May 2020

Abstract excerpt

Podosomes play crucial roles in macrophage adhesion and migration. Wiskott-Aldrich syndrome protein (WASP; also known as WAS)-mediated actin polymerization is one of the key events initiating podosome formation. Nevertheless, membrane signals to trigger WASP activation at macrophage podosomes remain unclear. Here, we show that phosphatidylinositol (3,4,5)-trisphosphate [PI(3,4,5)P3] lipids are enriched at the...

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PMID: 32393599
DOI: 10.1242/jcs.234385

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