Article
Sequential signals toward podosome formation in NIH-src cells.
The Journal of cell biology - 14 Jul 2008
Oikawa Tsukasa, Itoh Toshiki, Takenawa Tadaomi
Abstract excerpt
Podosomes (also termed invadopodia in cancer cells) are actin-rich adhesion structures with matrix degradation activity that develop in various cell types. Despite their significant physiological importance, the molecular mechanism of podosome formation is largely unknown. In this study, we investigated the molecular mechanisms of podosome formation. The expression of various phosphoinositide-binding domains...
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