Inactivation of the H-2Klk gene could involve the substitutions of methylated CpGs.

doi:10.1111/j.1744-313x.1990.tb00866.x

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Article

Inactivation of the H-2Klk gene could involve the substitutions of methylated CpGs.

Journal of immunogenetics - 1 Jan 2000

Sim B C, Grosveld F G, Hui K M

Abstract excerpt

By the isolation of overlapping cosmid clones and 'chromosome walking' studies from the H-2Kk gene, we have obtained cosmid clones encoding the H-2Klk gene from two separate cosmid libraries. The nucleotide sequence of one of the clones was determined. The cloned H-2Klk gene could be transcribed...

Topics

Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
Chromosome Walking
Cloning, Molecular
Cosmids
Genes, MHC Class I
Genetic Linkage
H-2 Antigens
Methylation
Mice
Molecular Sequence Data
Mutation

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