Article
Enfuvirtide cerebrospinal fluid (CSF) pharmacokinetics and potential use in defining CSF HIV-1 origin.
Antiviral therapy - 1 Jan 2008
Price Richard W, Parham Robin, Kroll Jing Lu, Wring Stephen A, Baker Brian, Sailstad Jeff, Hoh Rebecca, Liegler Teri, Spudich Serena, Kuritzkes Daniel R, Deeks Steven G
Abstract excerpt
BACKGROUND: Enfuvirtide is a potent inhibitor of systemic HIV-1 replication, but its penetration into the human central nervous system (CNS) has not been analysed. Here, we define cerebrospinal fluid (CSF) enfuvirtide pharmacokinetics and present a case illustrating the use of enfuvirtide as a probe to trace the origins of CSF HIV-1 quasispecies. METHODS: Enfuvirtide CSF pharmacokinetics were assessed in 18 CSF...
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