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Article

TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner.

Developmental biology - 1 Aug 2008

Zhao Hu, Oka Kyoko, Bringas Pablo, Kaartinen Vesa, Chai Yang

Abstract excerpt

TGF-beta superfamily members signal through a heteromeric receptor complex to regulate craniofacial development. TGF-beta type II receptor appears to bind only TGF-beta, whereas TGF-beta type I receptor (ALK5) also binds to ligands in addition to TGF-beta. Our previous work has shown that conditional inactivation of Tgfbr2 in the neural crest cells of mice leads to severe craniofacial bone defects. In this study,...

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Identifiers

PMID: 18572160
DOI: 10.1016/j.ydbio.2008.03.045
PMCID: PMC3629921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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