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Article

Signaling through Tgf-beta type I receptor Alk5 is required for upper lip fusion.

Mechanisms of development - 1 Jan 2000

Li Wai-Yee, Dudas Marek, Kaartinen Vesa

Abstract excerpt

Cleft lip with or without cleft palate is one of the most common congenital malformations in newborns. While numerous studies on secondary palatogenesis exist, data regarding normal upper lip formation and cleft lip is limited. We previously showed that conditional inactivation of Tgf-beta type I receptor Alk5 in the ectomesenchyme resulted in total facial clefting. While the role of Tgf-beta signaling in palatal...

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Identifiers

PMID: 18586087
DOI: 10.1016/j.mod.2008.06.003
PMCID: PMC2593738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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