Article
The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development.
Development (Cambridge, England) - 1 Nov 2001
Ferguson C A, Tucker A S, Heikinheimo K, Nomura M, Oh P, Li E, Sharpe P T
Abstract excerpt
The gene for activin betaA is expressed in the early odontogenic mesenchyme of all murine teeth but mutant mice show a patterning defect where incisors and mandibular molars fail to develop but maxillary molars develop normally. In order to understand why maxillary molar tooth development can proceed in the absence of activin, we have explored the role of mediators of activin signalling in tooth development....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.