Article
Alk8 is required for neural crest cell formation and development of pharyngeal arch cartilages.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2003
Payne-Ferreira T L, Yelick P C
Abstract excerpt
The type I TGFbeta family member receptor alk8 acts in bone morphogenetic protein (BMP) signaling pathways to establish dorsoventral patterning in the early zebrafish embryo. Here, we present evidence that alk8 is required for neural crest cell (NCC) formation and that alk8 signaling gradients direct the proper patterning of premigratory NCCs. We extend our previous functional studies of alk8 to demonstrate that...
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