Article
Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.
Cancer letters - 18 Oct 2008
Tischkowitz Marc D, Yilmaz Ahmet, Chen Long Q, Karyadi Danielle M, Novak David, Kirchhoff Tomas, Hamel Nancy, Tavtigian Sean V, Kolb Suzanne, Bismar Tarek A, Aloyz Raquel, Nelson Peter S, Hood Lee, Narod Steven A, White Kirsten A, Ostrander Elaine A, Isaacs William B, Offit Kenneth, Cooney Kathleen A, Stanford Janet L, Foulkes William D
Abstract excerpt
Checkpoint kinase 2 (CHEK2) is a protein involved in arresting cell cycle in response to DNA damage. To investigate whether it plays an important role in the development of prostate cancer (PRCA) in the Ashkenazi Jewish (AJ) population, we sequenced CHEK2 in 75 AJ individuals with prostate, breast, or no cancer (n=25 each). We identified seven coding SNPs (five are novel) that changed the amino-acid sequence,...
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