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Article

Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.

The Israel Medical Association journal : IMAJ - 1 Nov 2007

Laitman Yael, Kaufman Bella, Lahad Ephrat Levy, Papa Moshe Z, Friedman Eitan

Abstract excerpt

BACKGROUND: Germline mutations in BRCA1 and BRCA2 genes account for only 20-40% of familial breast cancer cases. The CHEK2 gene encodes a checkpoint kinase, involved in response to DNA damage, and hence is a candidate gene for breast cancer susceptibility. Indeed, the CHEK2*1100delC truncating mu...

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Source

Identifiers

PMID: 18085035

Genes

CHEK2
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18085035-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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